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IRAK-1-4 Inhibitor I
CAS No. 509093-47-4
IRAK-1-4 Inhibitor I( IRAK-1/4 Inhibitor I )
Catalog No. M14746 CAS No. 509093-47-4
IRAK-1-4 Inhibitor I is a potent, dual inhibitor of IRAK4 and IRAK1 with IC50 of 0.2 uM and 0.3 uM, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 45 | In Stock |
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| 5MG | 65 | In Stock |
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| 10MG | 101 | In Stock |
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| 25MG | 232 | In Stock |
|
| 50MG | 437 | In Stock |
|
| 100MG | 626 | In Stock |
|
| 500MG | 1341 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameIRAK-1-4 Inhibitor I
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NoteResearch use only, not for human use.
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Brief DescriptionIRAK-1-4 Inhibitor I is a potent, dual inhibitor of IRAK4 and IRAK1 with IC50 of 0.2 uM and 0.3 uM, respectively.
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DescriptionIRAK-1-4 Inhibitor I is a potent, dual inhibitor of IRAK4 and IRAK1 with IC50 of 0.2 uM and 0.3 uM, respectively; displays IC50 of >10 uM against a panel of 27 other kinases, including the most closely homologous (outside of the IRAK family) Lck and pp60SRC; eliminates the LPS-induced increases in Bcl10, NF-κB, and IL-8 in human intestinal epithelial cells.
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In Vitro——
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In Vivo——
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SynonymsIRAK-1/4 Inhibitor I
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PathwayImmunology/Inflammation
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TargetIRAK
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RecptorIRAK-1|IRAK-4
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Research AreaInflammation/Immunology
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Indication——
Chemical Information
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CAS Number509093-47-4
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Formula Weight395.4
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Molecular FormulaC20H21N5O4
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=C(NC1=NC2=CC=CC=C2N1CCN3CCOCC3)C4=CC=CC([N+]([O-])=O)=C4
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Chemical NameBenzamide, N-[1-[2-(4-morpholinyl)ethyl]-1H-benzimidazol-2-yl]-3-nitro-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Powers JP, et al. Bioorg Med Chem Lett. 2006 Jun 1;16(11):2842-5.
2. Bhattacharyya S, et al. Am J Physiol Gastrointest Liver Physiol. 2007 Aug;293(2):G429-37.
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